# Epigenetics: The Science of Change - Author: **Bob Weinhold** - Document Tags: [[Epigenetics]] - [URL link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392256/)  ## Highlights - Many types of epigenetic processes have been identified—they include methylation, acetylation, phosphorylation, ubiquitylation, and sumolyation. ([View Highlight](https://read.readwise.io/read/01hgyyp2z6kmqafc6371wdph03)) --- - DNA methylation. This is the addition or removal of a methyl group (CH3), predominantly where cytosine bases occur consecutively. ([View Highlight](https://read.readwise.io/read/01hgyyr2p96sq185qnw9f6k6nc)) --- - Most epigenetic modification, by whatever mechanism, is believed to be erased with each new generation, during gameto-genesis and after fertilization. However, one of the more startling reports published in 2005 challenges this belief and suggests that epigenetic changes may endure in at least four subsequent generations of organisms. ([View Highlight](https://read.readwise.io/read/01hgyys7a74wmpx31cjb8maf20)) --- - Substances aren’t the only sources of epigenetic changes. ([View Highlight](https://read.readwise.io/read/01hgyyvscm4bc07rp9kne0ds82)) --- - mental health may be affected by epigenetic changes ([View Highlight](https://read.readwise.io/read/01hgyyx67gtyk72v25njv3xaya)) --- - The accumulated evidence indicates that many genes, diseases, and environmental substances are part of the epigenetics picture. However, the evidence is still far too thin to form a basis for any overarching theories ([View Highlight](https://read.readwise.io/read/01hgyyyj8b1tbp8d9e5gns44jw)) ---